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The administration of nerve block anesthesia in combination with sevoflurane to patients with uterine fibroids undergoing myomectomy may significantly reduce the stress response, maintain hemodynamic stability, and reduce adverse reactions and cognitive impairment.

Sevoflurane is a newer inhalation anesthetic with broad market prospects and few side effects. Numerous experiments have shown sevoflurane to have stable hemodynamics, very low blood gas partition coefficient, and rapid induction.
Respiratory depressant and cardiovascular effects are relatively smaller with sevoflurane than with isoflurane. This medication does not give rise to allergic reactions; however, it may cause mild irritation in the mucus membrane of the eyes. Another important characteristic that makes sevoflurane an ideal inhalation anesthetic is the adjustability of its depth of anesthesia. This study, published in the journal Contrast Media & Molecular Imaging, evaluatds the effects of the combined application of sevoflurane and nerve block anesthesia on hemodynamics and stress response in patients with uterine fibroids undergoing myomectomy.

The study selected 100 patients who underwent myomectomy as research subjects. The participants were distributed equally among the control and observation groups. The control group was administered both remifentanil intravenous compound anesthesia and propofol. The observation group participants received nerve block anesthesia and sevoflurane. The two groups were compared for hemodynamic changes and stress response at T1 (5 minutes before anesthesia), T2 (30 minutes following pneumoperitoneum), and T3 (at the completion of the operation).

The study results revealed that the stress responses recorded at T2 and T3 were lower in the observation group than in the control group. A similar decline was observed in the hemodynamic indicators in the observation group as compared to the control group. One day following the surgery, the Simple Mental Scale State scores were higher in the observation group. Moreover, the incidence of adverse effects was lower in the observation group.

In summary, sevoflurane combined with nerve block can greatly minimize the level of stress reaction in patients undergoing laparoscopic myomectomy, preserve the relative stability of hemodynamics, and lessening the impact of surgery on patients’ cognitive performance. It increases anesthesia and surgical safety and is an optimal method of anesthesia.

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Fan, S., & Li, S. (2022). Application Effect of Sevoflurane Combined with Nerve Block Anesthesia in Surgical Anesthesia in Patients with Uterine Fibroids. Contrast Media & Molecular Imaging, 2022, 9983851. doi:10.1155/2022/9983851