This study focused on rates of hematologic inflammation in patients with age-related macular degeneration (AMD). Patients with wet AMD and dry AMD were included. The goal of the study was to find correlation patterns between hematologic inflammation and AMD, which could be useful for diagnostic and therapeutic purposes.
This study analyzed data from 60 patients with dry AMD, 60 patients with wet AMD, and 71 healthy control subjects. Patients were stratified according to demographic information and were tested to determine their neutrophil-to-lymphocyte ratio (NLR), their platelet-to-lymphocyte ratio, and their monocyte-to-lymphocyte ratio (MLR). These ratios were calculated for each patient group and analyzed using receiver operating characteristic curve analysis.
The researchers ultimately found that the NLR and MLR were significantly higher in the patients with wet AMD, which they interpreted as a sign of low-grade inflammation in this group .
Source: Karahan, M., Hazar, L., Erdem, S., Ava, S., Dursun, M. E., Demirtaş, A. A., & Keklikçi, U. (2021). Is there a relationship between hematological inflammatory parameters and age-related macular degeneration? Therapeutic Advances in Ophthalmology, 13, 251584142110105. https://doi.org/10.1177/25158414211010550