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Hesperidin is a plant chemical found in citrus fruits, such as oranges, grapefruit, lemon, and tangerines, that may be taken as a dietary supplement. A study found that hesperidin (HSP) may be an effective anticancer treatment.

In the medical community, cancer has grown to be a challenging concern due to the nature of the disease. Conventional treatments may exhibit side effects or anticancer resistance over time. The need for more potent and selective anticancer medications is evident, despite the fact that some conventional treatments are still beneficial for cancer patients. Hesperidin may be a potential candidate that targets cellular proteins and suppresses the formation of tumors. 

In search of potent anticancer agents, naturally occurring compounds have been researched and admired due to their structural diversity. One study was conducted to verify the anticancer properties of hesperidin.

  1. Findings showed that citrus fruits contain a high concentration of Hesperidin (HSP), a phytoestrogen, which has anti-cancer properties and effects that interfere with various cell-signaling pathways. 
  2. The cell cycle regulation, apoptosis, estrogen metabolism, and antioxidant-related proteins are only some of the biological proteins that hesperidin (HSP) can target to disrupt the growth of tumors.
  3. Hesperidin (HSP) has demonstrated impressive synergistic effects in combination therapy and has reportedly been able to overcome problems with multidrug cancer resistance, creating a stronger defense system. HSP’s anticancer properties could be a result of its structural chemistry.

Overall, hesperidin (HSP) has potential anticancer effects against many types of cancer, including breast, lung, prostate, liver, and colon cancer. Consequently, this phytochemical may be a useful alternative medicine for the treatment of cancer, either by itself or in combination with other substances. 

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While HSP has beneficial pharmacokinetic qualities, it may have toxic effects in the liver. Long-term clinical studies are needed to further learn about the properties and effects of HSP and its potential use for cancer treatment. 




Sohel, M., Sultana, H., Sultana, T., Al Amin, M., Aktar, S., Ali, M. C., Rahim, Z. B., Hossain, M. A., Al Mamun, A., Amin, M. N., & Dash, R. (2022). Chemotherapeutic potential of hesperetin for cancer treatment, with mechanistic insights: A comprehensive review. Heliyon, 8(1), e08815. https://doi.org/10.1016/j.heliyon.2022.e08815