Vitamin D Receptor Polymorphisms and Vitiligo Susceptibility

Vitamin D receptor polymorphisms may impact vitiligo susceptibility, and this study analyzes that possibility in various geographic regions as it relates to specific polymorphisms.

Although the specific conclusions are still being debated, previous research indicates associations between vitamin D receptor (VDR) polymorphisms and susceptibility to vitiligo. This study, published in the Journal of Cosmetic Dermatology, used a retrospective meta-analysis of prior research on vitiligo to attempt to establish this association. The researchers specifically targeted VDR Apal, Taql, and Bsml polymorphisms and their relationship to vitiligo in n Asian, Arab, European, and Latin American participants.

For this study, VDR polymorphisms in patients with vitiligo, as well as in healthy controls, were identified using PubMed/Medlin and Embase databases. The analysis included 13 published papers with a total of 2,034 patients with vitiligo and 2,771 controls. In the Asian group (but not in the European or Arabic groups), a link was found between the VDR Apal A allele and vitiligo. A link between the VDR Apal polymorphism and vitiligo was also discovered in the Asian group using recessive, dominant, and homozygote contrast models.

Additional results are described in further detail, including a relationship between vitiligo and the B allele, discovered via analysis of the VDR Bsml polymorphism. This relationship was significant, but no connection was found between vitiligo and the Taql or Fokl polymorphisms. The researchers conclude by noting that the only association between VDR polymorphisms and vitiligo was found in the Asian group, and only among the Apal and Bsml polymorphisms. No other associations were found in the European, Asian, Arab, or Latin American populations, but further research on more specific genetic subgroups could yield additional associations.

Reference

Lee, Y. H., & Song, G. G. (2022). Association between vitamin D receptor polymorphisms and vitiligo susceptibility: An updated meta-analysis. J Cosmet Dermatol. doi:10.1111/jocd.15474

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