Cardiomyopathy

A recent study examined how frequently the V122I genetic variant leads to heart failure in older Black individuals. This research sought to identify how specific genes can influence the development and presentation of transthyretin amyloid cardiomyopathy. Transthyretin amyloid cardiomyopathy (ATTR-CM) remains an underdiagnosed cause of heart failure among older individuals. The V122I variant, associated with...

Cardiac amyloidosis, an underdiagnosed cause of heart failure, may present with persistent symptoms even under optimal medical therapy. Early diagnosis and novel treatments may offer hope for better outcomes. Cardiac amyloidosis is a severe form of restrictive cardiomyopathy that can elude diagnosis. Persistent heart failure symptoms may be a red flag for amyloidosis in the...

Knowledge of red flags suggesting cardiac transthyretin amyloidosis is crucial for identifying at-risk patients and establishing the correct diagnosis. Cardiac amyloidosis is caused by the extracellular deposition of misfolded proteins in cardiac tissue. Wild-type transthyretin amyloidosis (wtATTR) is the most common form of cardiac amyloidosis. It mostly affects elderly patients, who usually present with heart...

This study highlights the clinical characteristics and healthcare resource use of patients at higher risk for wild-type transthyretin amyloid cardiomyopathy identified using a machine learning model. Transthyretin amyloid cardiomyopathy (ATTR-CM) can lead to heart failure (HF). If there is a delay in the diagnosis of wild-type ATTRCM (ATTRwt-CM), patients may undergo multiple hospital visits before...

After elective percutaneous coronary intervention, prolonged bivalirudin infusion protects against procedural myocardial injury. Procedural myocardial injury (PMI) is common after elective percutaneous coronary intervention (ePCI) and is linked to an increased risk of subsequent adverse cardiac events. In the post-PCI period, PMI is characterized by an increase in cardiac troponin I (cTnI) levels above the...

The positive correlation of bile acid levels in biliary atresia to myocardial structural changes highlights their potential causative association with cardiomyopathy in these patients. Cirrhotic cardiomyopathy comprises pathologic cardiac structural and functional changes in cirrhotic patients. It has a prevalence of approximately 30% and is a major cause of morbidity and peri-operative mortality in these...

The positive correlation of bile acid levels in biliary atresia to myocardial structural changes highlights their potential causative association with cardiomyopathy in these patients. Cirrhotic cardiomyopathy comprises pathologic cardiac structural and functional changes in cirrhotic patients. It has a prevalence of approximately 30% and is a major cause of morbidity and peri-operative mortality in these...

Cardiac amyloidosis, particularly wild-type transthyretin amyloidosis, is often underdiagnosed, affecting mainly elderly men. Recognizing red flags suggestive of wild-type transthyretin amyloidosis is important for timely diagnosis and allows patients to benefit from effective therapies. Cardiac amyloidosis is a group of diseases characterized by extracellular deposition of misfolded proteins in the heart. Three types of amyloidosis...

A recent study develops a more efficient model to assess the likelihood of transthyretin amyloid cardiomyopathy (ATTR-CM) in patients with heart failure (HF), improving early identification and potential treatment for this underrecognized condition. The propensity model developed in the study demonstrated a 71.9% sensitivity and 95.2% specificity in identifying patients with HF who are more...