Multiple Sclerosis

Eculizumab substantially mitigated the risk of relapse in comparison to a placebo and was found to be well-tolerated. Aquaporin-4 immunoglobulin G-positive neuromyelitis optica spectrum disorder (AQP4-IgG + NMOSD) is an autoimmune central nervous system disorder characterized by relapses that lead to accumulating disability. Chronic immunosuppressive therapy (IST) is the primary treatment for AQP4-IgG + NMOSD,...

The accuracy of distinguishing relapsing–remitting multiple sclerosis from aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder and myelin oligodendrocyte glycoprotein antibody-associated disease can be achieved with high precision using cortical lesions, central vein sign, and optic nerve markers. When serologic testing for relapsing-remitting multiple sclerosis (RRMS), aquaporin-4 antibody-positive neuromyelitis optica spectrum disorder (AQP4-NMOSD), and myelin oligodendrocyte glycoprotein...

The pathogenesis of MS is complex and may relate to various viral conditions. This study analyzes the way that various viruses affect MS onset, and what that can teach us about future therapies. Compared to other self-limiting myelin disorders, multiple sclerosis (MS) is associated with chronic inflammation in the central nervous system. Although its cause...

The effects of COVID-19 vaccination on people with multiple sclerosis has not been studied in sufficient detail. This study provides an analysis of the available data. COVID-19 infection as well as the various COVID-19 vaccines have caused health complications for some patients with certain medical conditions. Despite the vaccine being available for a number of...

The gut microbiome of patients with multiple sclerosis appears to be altered in characteristic ways that may inform future therapeutic approaches. Although multiple sclerosis (MS) is a chronic disease that affects the brain and spinal cord, it has been hypothesized that a disrupted bacterial and viral gut microbiota contributes to the pathogenesis of the disease....

Researchers were able to use AI-generated images as accurately as MRI-acquired images to identify lesions.  Although cortical multiple sclerosis (MS) lesions are clinically significant, they are often hard to evaluate using conventional clinical MRI. Double inversion recovery (DIR) and phase-sensitive inversion recovery (PSIR) are more sensitive but tend to be unavailable in many clinical settings. In...

People with MS deal with various types of burdensome effects of their disease. This study analyzed these effects in the context of the COVID-19 pandemic. The COVID-19 pandemic had wide-ranging impacts on mental health symptoms and quality of life. This change was apparent in both the general population and those with varying mental and physical...

Sleeping less than seven hours per night and self-reported low sleep quality during adolescence associated with risk for developing MS Insufficient sleep and low sleep quality during adolescence may increase the risk for subsequently developing multiple sclerosis, according to a study published online Jan. 23 in the Journal of Neurology, Neurosurgery & Psychiatry. Torbjörn Åkerstedt,...

This study provides an analysis of how disease personification affects outcomes over time in patients with multiple sclerosis. Many patients with chronic illness ascribe human characteristics to their conditions. According to illness personification theory, this ascription can impact their adaptation and the way that they relate to their illness, with various possible methods ranging from...