Oncology

Emerging research highlights disparities in the diagnosis, treatment, and quality-of-life outcomes of prostate cancer in sexual minorities, emphasizing the urgent need for more culturally responsive healthcare practices. Further studies will provide healthcare professionals with the necessary tools to deliver better care to these underrepresented patient populations. Prostate cancer affects men across all sexual orientations, yet...

Dexamethasone decreases the incidence of docetaxel-induced oral mucositis in patients suffering from breast cancer in a dose-dependent manner. Pharmaceutical formulations containing docetaxel, an effective chemotherapeutic agent for the treatment of breast cancer, commonly lead to the development of oral mucositis (OM). To prevent the fluid retention that is associated with docataxel use in breast cancer...

Psychologically vulnerable breast cancer patients with less education, low social support, low patient activation, and younger age benefited most from nurse navigation intervention. Breast cancer patients with high levels of distress at the time of diagnosis tend to be at risk for physical symptoms and long-term distress. This randomized controlled trial (RCT) evaluated whether breast...

Hypo-fractionated ablative liver radiotherapy is a safe and well-tolerated modality for treating metastatic breast cancer, with excellent local control. Metastasis in breast cancer frequently involves the lungs, bones, and liver. Advancement in the field of radiologic imaging has allowed for the identification of limited metastatic disease in cancer patients. This retrospective cohort described hypo-fractionated liver...

This study provides a review of the interaction between cancer and kidney disease to develop nephroprotective strategies during chemotherapy. The inter-relationship between cancer and kidney disease emphasizes the importance of onco-nephrology. Chemotherapeutic agents can affect renal function and result in acute kidney injury (AKI) or chronic kidney disease (CKD) in cancer survivors. Moreover, the co-existence...

This study reviewed the role of extracellular vesicles in renal cell carcinoma progression and their potential future clinical applications. Extracellular vesicles (EVs) are nanosized vesicles released into the extracellular spaces by most cell types, including cancer and non-cancer cells. EVs secreted by renal cell carcinoma (RCC) play a role in various steps of cancer progression....

This article elucidates the metabolic pathways of rapamycin and its derivatives, intending to propose a strategy for implementing personalized medicine. Rapamycin (sirolimus) and its derivatives are immunosuppressants and chemotherapeutic agents used in cancer treatment. As the paradigm shifts towards personalized medicine, it is essential to identify the factors impacting the effectiveness of these drugs. A...

Fascin-1 has a promising role as a biomarker in urologic cancers. Metastasis is the leading cause of poor prognosis in urologic cancers. Early diagnosis and effective treatments for metastatic cancer would improve the survival rate. Fascin-1 is an actin-binding protein involved in cell division, migration, and intercellular interactions. There is frequent upregulation of fascin-1 in...

A recently published study reveals key factors contributing to the underutilization of treatment in multiple myeloma patients. The study emphasizes the importance of understanding patients’ perceptions, the role of physician recommendations, and individual decision-making preferences. Treatment underutilization in multiple myeloma is influenced by patient perceptions, doctor recommendations, and individual decision-making practices. No racial differences were...