Specialty

A new ex vivo study shows that the AQP4-IgG/AQP4 immunocomplex-mediated cytokine response plays a vital role in neuromyelitis optica spectrum disorder pathogenesis. Neuromyelitis optica spectrum disorder (NMOSD) is an autoimmune inflammatory disease particularly affecting the optic nerves and spinal cord. Unlike multiple sclerosis (MS), NMOSD exhibits unique clinical features and diagnostic criteria, with aquaporin-4 immunoglobulin...

A comprehensive review highlights the crucial role of the IL-23/IL-17 axis in psoriasis management, showcasing the efficacy of targeted biological therapies. These findings represent a significant breakthrough, providing effective alternatives to conventional treatments with improved safety profiles. Psoriasis, a complex inflammatory skin disease, impacts millions worldwide. The disease is driven by genetic and environmental factors...

A recent meta-analysis explores how psychological interventions can accelerate wound healing in psoriasis patients post-surgery, highlighting the need for a holistic approach to patient care. This meta-analysis investigated the impact of psychological interventions on surgical site wound healing in patients with psoriasis. The researchers synthesized data from multiple studies,  adhering to PRISMA guidelines, to provide...

METTL3 promoted glycolysis by binding with the c-Myc/WDR5 protein complex, mediating the progression of triple-negative breast cancer in an animal model and cell culture study. The oncogene c-Myc drives the malignant transformation of triple-negative breast cancer (TNBC). WDR5 is a transcription cofactor that plays an important role in the regulation of c-Myc-dependent transcription. This prompts...

A recently published thesis reports that the implementation of a coping interventional education package has a positive impact on postmenopausal women in terms of overcoming stress. The educational package can be provided in multiple settings, facilitating stress management. The menopausal transition can be an emotionally and physically challenging process, which may serve as a potential...

A Mendelian randomization analysis study has demonstrated an increased risk of multiple myeloma in individuals genetically susceptible to primary sclerosing cholangitis. Multiple myeloma is a malignant proliferative disease with rapidly increasing incidence and mortality and a poor prognosis. Recent studies have highlighted the potential relationship between multiple myeloma and autoimmune diseases.  In this Mendelian randomization...

METTL3 promoted glycolysis by binding with the c-Myc/WDR5 protein complex, mediating the progression of triple-negative breast cancer in an animal model and cell culture study. The oncogene c-Myc drives the malignant transformation of triple-negative breast cancer (TNBC). WDR5 is a transcription cofactor that plays an important role in the regulation of c-Myc-dependent transcription. This prompts...

A newly published case report illustrates the diagnostic and monitoring benefits of dopamine testing for patients who are suspected or at risk of having dopamine-secreting head and neck paragangliomas. Key Points Paragangliomas are rare neuroendocrine tumors that originate from neural crest cells. Hypersecretory paragangliomas, such as those that secrete dopamine, are rare and may go...

The existence of pulmonary metastatic follicular thyroid carcinoma with the presence of a primary thyroid neoplasm is a rare phenomenon that should be differentiated from ectopic thyroid tissues and should be considered in the differential diagnosis. The presence of benign and malignant pulmonary thyroid tissue is a rare finding. Individuals with ectopic thyroid tissue can...