Specialty

Compared to the general population, the incidence of anxiety in perimenopausal women was relatively greater and was associated with impaired quality of life in perimenopausal women in a questionnaire-based study. Vasomotor symptoms in perimenopausal women have a significant effect on the quality of life of perimenopausal women. In addition to these symptoms, perimenopausal women also...

A screening of the differentially expressed genes based on the Gene Expression Omnibus database and further gene enrichment analysis indicates that the tyrosine kinase-binding protein TYROBP is a potential prognostic marker for multiple myeloma. Multiple myeloma is a refractory hematological cancer characterized by the malignant proliferation of plasma cells. The tyrosine kinase-binding protein TYROBP mediates...

Double-hit newly diagnosed multiple myeloma patients with minimal residual disease positivity have a poor prognosis compared to patients with minimal residual disease negativity, according to the results of a recent cohort study. Autologous stem cell transplantation (ASCT) is one of the novel therapeutic approaches that are beneficial for newly diagnosed multiple myeloma (NDMM) patients. The...

A random forest radiomics model achieved satisfactory diagnostic performance, and models based on joint CET1 and T2-weighted imaging demonstrated better performance than single-sequence models in differentiating spinal multiple myeloma from metastases.  Spinal metastases and spinal multiple myeloma have similar radiographic characteristics, making accurate differentiation a necessity for precision therapy.  This retrospective study established and assessed...

A new cohort study reports that soluble B-cell maturation antigen is present in the lacrimal fluid of multiple myeloma patients, with evidence of pinocytosis as the underlying mechanism contributing to the development of keratopathy in these patients. Belantamab is an anti-B-cell maturation antigen (anti-BCMA) antibody–drug conjugate approved for the pharmacological treatment of refractory multiple myeloma....

A retrospective analysis finds high-risk fluorescent in situ hybridization markers useful for stratifying real-world survival outcomes in newly diagnosed multiple myeloma patients. Interphase fluorescent in situ hybridization (iFISH) remains the standard of care for assessing prognosis in patients with newly diagnosed multiple myeloma (NDMM). There is, however, limited data regarding iFISH-based real-world survival outcomes. In...

Researchers have identified several clinical characteristics of psoriasis patients that may increase the risk of developing psoriatic arthritis.  A single-center, retrospective cohort study examined the clinical profiles of psoriasis patients to determine the precursors of psoriatic arthritis (PsA), aiming to bridge the gap between psoriasis management and the identification of psoriatic arthritis risk. The study’s...

An analysis of microarray data demonstrated impaired apoptosis signaling pathways in CD14+ monocytes in psoriatic arthritis patients, concluding that their increased levels may play an essential role in the disease pathogenesis. Psoriatic arthritis (PsA) is a complex chronic inflammatory condition affecting approximately 30% of patients with psoriasis, leading to functional impairments and increased mortality risk. ...

A prospective follow-up study found that psoriatic arthritis patients with higher synovial immunohistochemical reactivity of IL-17A, DKK1, and TGF-β1 are more likely to benefit from early initiation of biologics. Psoriatic arthritis (PsA) is a chronic inflammatory disease affecting joints and skin in patients with psoriasis. It exhibits progressive and destructive joint changes, with significant pathological...