April 24, 2023

The positive correlation of bile acid levels in biliary atresia to myocardial structural changes highlights their potential causative association with cardiomyopathy in these patients. Cirrhotic cardiomyopathy comprises pathologic cardiac structural and functional changes in cirrhotic patients. It has a prevalence of approximately 30% and is a major cause of morbidity and peri-operative mortality in these...

High-flow nasal therapy is a promising therapy for improving oxygenation and patient comfort during transcatheter aortic valve replacement and other medical procedures. Transcatheter aortic valve replacement (TAVR) is a minimally invasive procedure used to treat aortic stenosis. TAVR patients, who are typically elderly and have multiple health conditions, may experience a common issue of hypoxia. ...

Consumption of small fish packed with omega-3 fatty acids was linked to a decreased risk of non-fatal and deadly cardiovascular disease over 10 years, especially among healthy individuals at low risk. Cardiovascular disease (CVD) has become a major cause of disease and death on a global scale. As a result, eating 1–2 meals centered on...

Levels of angiotensin-converting enzyme 2 vary significantly in patients who are given angiotensin-converting enzyme inhibitors and angiotensin receptor blockers. Individuals taking angiotensin-converting enzyme inhibitors typically have reduced angiotensin-converting enzyme-2 levels. Angiotensin-converting enzyme-2 levels show a notable positive correlation with the female gender. Angiotensin-converting enzyme 2 (ACE2) is one of the major enzymes of the renin–angiotensin–aldosterone...

Recent research highlights the crucial role of noncoding RNAs in the pathogenesis of systemic lupus erythematosus, offering a deeper understanding of the disease and opening doors for targeted therapies. Noncoding RNAs, including microRNAs, long noncoding RNAs, and circular RNAs, contribute significantly to the pathogenesis of systemic lupus erythematosus. Dysregulation of noncoding RNAs can impact signaling...

A recent study highlights the potential of Janus kinase inhibitors in treating systemic lupus erythematosus by targeting specific molecular pathways and improving traditional treatment strategies. Janus kinase inhibitors target Janus kinase signal transduction and transcriptional activator pathway, which plays a central role in inflammation in systemic lupus erythematosus inflammation. Janus kinase inhibitors may improve systemic...

Anifrolumab treatment leads to earlier and more frequent attainment of lupus low disease activity state in patients with systemic lupus erythematosus. This suggests the potential for the drug to be incorporated into a treat-to-target approach for managing systemic lupus erythematosus patients. Anifrolumab increases lupus low disease activity state attainment in patients with systemic lupus erythematosus....

A recent study demonstrates the presence of Schwann cell remyelination in multiple sclerosis (MS) cases, including in the cerebrum, brainstem, and spinal cord, highlighting the potential for new therapeutic strategies. The study found evidence of Schwann cell remyelination in the brain and spinal cords of 6 out of 14 autopsied MS cases. Schwann cell remyelination...

A recent study explores the role of amyloidogenic evolvability in multiple sclerosis and multiple system atrophy, potentially unveiling novel intervention strategies for these chronic degenerative conditions. Multiple sclerosis and multiple system atrophy, both characterized by impaired oligodendrocytes, may share a common mechanism through amyloidogenic evolvability. The non-amyloidogenic homologue β-synuclein may modulate amyloidogenic evolvability, influencing the...