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Both hormonal and non-hormonal therapies are available for treating postmenopausal symptoms. Menopause is the discontinuation of ovarian function and is marked by 12 consecutive months of amenorrhea. It occurs at a median age of 51 years. Postmenopausal symptoms that can be managed include vasomotor symptoms (VMS), vulvovaginal atrophy, sexual dysfunction, dyspareunia, frequent urination, and osteoporosis. ...

Tumor mutational burden (TMB) can function as a biomarker for response to immunotherapy. Understanding how to accurately test TMB and understanding the implications of variation in the results can inform treatment. This study, published in Clinical Research (Excluding Clinical Trials), analyzed the genomic profiles of patients with cancer to assess TMB prevalence and variability, and its...

In this MD Newsline exclusive interview with internal medicine physician Dr. Greg Hall, we discuss Dr. Hall’s development of Sequence Multivitamins for African Americans. We also discuss how Sequence Multivitamins are different from some of the other leading multivitamin brands. MD Newsline: What findings from clinical practice and medical research influenced your decision to develop...

Transperitoneal and extraperitoneal approaches to three-dimensional laparoscopic radical prostatectomy have similar clinical outcomes, according to a recent retrospective study. Radical prostatectomy is among the best treatments for localized prostate cancer. Three-dimensional laparoscopic radical prostatectomy (3D LRP) has two main surgical approaches, namely 3D extraperitoneal LRP (3D ELRP) and 3D transperitoneal LRP (3D TLRP). There is...

This study found that, over time, treatment with sunitinib resulted in an increasing prevalence of hypogonadism among male patients diagnosed with metastatic renal cell carcinoma. However, administering testosterone replacement therapy led to clinically significant improvements in quality of life. Metastatic renal cell carcinoma (mRCC) is a challenging disease to treat, and single-agent tyrosine kinase inhibitors...

A nurse-led strategy effectively reduced blood pressure and cholesterol levels in people with HIV in a randomized trial. People with HIV (PWH) have a higher atherosclerotic cardiovascular disease risk, but they face unique barriers to its prevention, such as changing models of HIV primary care. A randomized clinical trial published in JAMA Network Open evaluated...

According to Mcleod Health and several studies African-American women suffer fibroids 2 to 3 times more than white women.  McLeod OB/GYN Dr. Monica Ploetzke stated “We also know that Black women tend to experience fibroids at a younger age and often more severely than their white counterparts.” One estimate is that 25% of African-American women...

Written by Nikki Meyer Edited by Lauren Weinand, M.D. Patients with cancer are a critical group in which to analyze COVID-19 vaccine response. This observational study, published in Blood, and presented at the 2021 ASH Annual Meeting & Exposition, examined COVID-19 vaccine response in patients with non-Hodgkin lymphomas (NHL) and chronic lymphocytic leukemia (CLL) who received the...

Compared to standard care, ambulatory care services are more cost-effective and are associated with decreased financial burden in the long term, according to the results of a randomized controlled trial.   Hidradenitis suppurativa (HS) is described as a chronic inflammatory cutaneous disorder and is associated with substantial treatment costs. The financial implications of the disease correlate...

The combination therapy of BEMPEG plus NIVO has shown promising results in treating advanced renal cell carcinoma. Although surgery and radiation therapy are the primary treatments for renal cell carcinoma (RCC), the introduction of immunotherapy has transformed the treatment landscape for advanced RCC. BEMPEG plus NIVO is a combination therapy with promising results in treating...