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Recent advancements have significantly transformed the treatment landscape for relapsed or refractory classic Hodgkin lymphoma. The emergence of innovative therapies promises better outcomes and sets the path for personalized treatment strategies. Classic Hodgkin lymphoma cure rates have improved with chemotherapy, yet 10–30% of patients experience relapse or refractory disease. The last decade has witnessed the...

Patients with multiple comorbidities in addition to melanoma may be less likely to receive appropriate treatment than patients without comorbidities. Clinicians and health systems are encouraged to address these inequalities in melanoma treatment. Disparities in the treatment of patients with melanoma exist in the United States and can have a negative impact on patient outcomes....

WEDNESDAY, April 14, 2021 (HealthDay News) — The U.S. Preventive Services Task Force (USPSTF) concludes that the current evidence is insufficient to ascertain the balance of benefits and harms of screening asymptomatic adults for vitamin D deficiency. These findings form the basis of a final recommendation statement published in the April 13 issue of the...

The pathologic response assessment of tumor specimens from patients undergoing systemic treatment provides an early indication of therapeutic efficacy. It predicts long-term survival as well. Grading systems for pathologic response were first developed for chemotherapy in select tumor types. However, the immunotherapeutic agents work differently from chemotherapeutic agents. Hence, a pan-tumor standardized scoring system for immune-related...

The number of studies on women’s health and multiple sclerosis (MS) has increased over recent years; however, knowledge gaps are still apparent. A recent scoping review addressed the available data. Women with multiple sclerosis (MS) face unique health challenges related to pregnancy, contraception, and menopause. Despite these challenges, limited studies are available that highlight these...

Critical conversations about the value of racial diversity and the importance of representation are taking place in all walks of life. These conversations are not theoretical exercises: they are meaningful and impactful practices in changing entrenched and damaging dynamics. In some cases, that damage can quite literally be a matter of life and death. Consider...

THURSDAY, Dec. 10, 2020 (HealthDay News) — Use of the ex vivo CRISPR-Cas9-based gene-editing platform to edit the erythroid enhancer region of BCL11A in hematopoietic stem and progenitor cells, producing CTX001, results in increased hemoglobin (Hb) among patients with transfusion-dependent ß-thalassemia (TDT) and sickle cell disease (SCD), according to a study published online Dec. 5...

THURSDAY, Oct. 22, 2020 (HealthDay News) — Flavan-3-ol intake is associated with lower systolic blood pressure, according to a study published online Oct. 21 in Scientific Reports. Javier I. Ottaviani, Ph.D., from Mars Inc. in McLean, Virginia, and colleagues examined cross-sectional associations between biomarker-estimated flavan-3-ol intake and blood pressure and other cardiovascular disease risk markers...

WEDNESDAY, Sept. 16, 2020 (HealthDay News) — For patients with multiple sclerosis (MS), financial toxicity is common and is associated with lifestyle-altering behaviors or care nonadherence, according to a study published online Aug. 18 in the Multiple Sclerosis Journal. Gelareh Sadigh, M.D., from Emory University in Atlanta, and colleagues surveyed adult MS patients visiting a...

TUESDAY, Nov. 3, 2020 (HealthDay News) — A cancer-causing compound in the drug metformin has resulted in the recall of two lots of the drug. Kansas City-based Nostrum Laboratories Inc., said Monday that it is voluntarily recalling its metformin HCl extended release tablets, USP 750 mg, according to a notice from the U.S. Food and...