Neurology

This study provides a longitudinal analysis of NMOSD outcomes using modern treatment methods and finds more promising results than past studies have shown. Even in patients who undergo immunosuppressive or immunomodulatory therapy, neuromyelitis optica spectrum disorder (NMOSD) tends to follow a progressive disease course with step-wise accumulation of disability over time. The influence of aquaporin-4...

The role of dsDNA in the cerebrospinal fluid of patients with NMOSD is not fully understood, but researchers have found that the levels are higher in this population. Neuromyelitis optica spectrum disorder (NMOSD) causes inflammation in the central nervous system and results in severe myelitis and optic neuritis. Double-stranded DNA (dsDNA) has been found to...

Cluster of inflammation markers positively associated with multiple sclerosis-related species Considerable alterations in the gut microbiota are seen in patients with multiple sclerosis, according to a study published online Jan. 5 in Genome Medicine. Florence Thirion, from Université Paris-Saclay, and colleagues conducted a case-control study involving 148 Danish cases with multiple sclerosis and 148 matched healthy...

Auditory-guided imagery can reduce multiple sclerosis patients’ fatigue and stigma and improve their mood. Multiple sclerosis (MS) is an inflammatory demyelinating disease of the white matter (WM) with progressive neurodegeneration, and it is the most common cause of neurological impairment in young adults. This double-blind clinical trial was published in BMC Neurology and undertaken on...

Masitinib can help patients by slowing down the progression of Expanded Disability Status Scale (EDSS)-based impairment. Multiple Sclerosis (MS) is a degenerative, demyelinating, and inflammatory disease of the central nervous system. In terms of medication, the clinical course of MS is diverse, with patients falling into two major categories. The first group, relapsing disease, is...

MS involves the interaction between an aberrant immune response and predisposing genetic components. Gut microbiome dysbiosis leads to neuroinflammation and the development of MS symptoms. The gut microbiome is an effective therapeutic target for the treatment of MS.  Multiple sclerosis (MS) is a neurodegenerative immune-mediated disease with a complex etiological basis. The disease is a...

IL-6 levels have been found to correlate with other autoimmune conditions, and this study provides some evidence that it is also a biomarker of NMOSD disease activity. Currently, there are no widely accepted soluble markers for disease progression or activity of neuromyelitis optica spectrum disorder (NMOSD). This article, published in the Journal of Neuroimmunology, analyzed...

Patients with NMOSD have increased COVID-19 risks, as determined by this meta-analysis. Individual susceptibility to COVID-19, as well as the ultimate outcome of the disease, can vary widely depending on comorbidities. This study, published in Multiple Sclerosis and Related Disorders, sought to determine the clinical features of COVID-19 in patients with neuromyelitis optica spectrum disorder...

Research shows physical activity can have positive results for people living with multiple sclerosis. A cross-sectional study including 41 patients with multiple sclerosis (MS) examined respiratory muscle strength, pulmonary function, and pelvic floor function. The study found MS patients with more advanced deterioration of pulmonary function and respiratory muscle strength also showed greater deterioration in...